Part 10

Pegfilgrastim (Neulasta)
Colony Stimulating Factor
use: decrease the incidence of infection (e.g. febrile neutropenia) in pt who is on chemotherapy
MOA: stimulation of granulocyte production

Infliximab (Remicade)
use: ankylosing spondylitis, RA
MOA: TNF alpha blocking agent

Ondansetron (Zofran)
5-HT3 receptor antagonist
use: prevention of nausea/ vomiting associated with chemotherapy

Rituxan (Rituximab)
Non-Hodgkin's Lymphoma and RA

Levaquin
Zocor
Revlimid

Part 9 (Top three drugs used in hospitals in 2006)

Erythropoiesis Stimulating Protein
Darbepoetin alpha (Aranesp)
Tx: Anemia in chronic kidney disease (CKD), pt on dialysis
Newer "poetin" with longer half life

Epoetin alpha (Epogen, Epocrit)
Tx: Anemia (lowering of RBCs) in CKD, CRF, zidovudine patient (Retrovir and also in Trizivir and Combivir), chemotherapy patient
SE: Thrombosis

Low Molecular Weight Heparin
Lovenox (Enoxaparin)
Low Mw heparin used in acute/prophylaxis DVT that may lead to pulmonary embolism, knee-hip replacement, MI surgery
1.5mg/kg Sc tend to be 30-40 mg once a day

Other LMwH Dalteparin (Fragmin), Tinzaparin (Innohep)

Part 8

Angiotensin II Receptor Antagonists

Irbesartan (Avapro) 150-300 mg once daily
Candesartan (Atacan) 4-32 mg once daily
Olmesartan (Benicar) 20-40 mg once daily
Losartan (Cozaar) 25-100 mg once daily
Valsartan (Diovan) 80-320 once daily
Eprosartan (Teveten) 400-800 once or twice daily
Telmisartan (Micardis) 20-80 once daily


5 Alpha-Reductase Inhibitors
for tx of BPH and male patterned baldness
Dutasteride (Avodart)
0.5 mg once daily

Finasteride (Propecia, Proscar)
5 mg per day Proscar BPH
1 mg per day Propecia male patterned baldness

Part 7

Etanercept (Enbrel)
antirheumatic (DMARD)
TNF blocking agent
Tx: RA, Ankylosing Spondylytis

Vytorin (Ezetimibe + Simvastatin)
Ezetimibe (Zetia) inhibits absorption of cholesterol at brush border of small intestine
Simvastatin (Zocor) HMGCoA reductase inhibitor

Fenofibrate (Tricor) 48-145 mg QDay
Fibric acid: reduces serum triglyceride
Tx: type 4 and 5 hyperlipidemia who are at risk of pancreatitis
MOA: inhibits triglyceride synthesis and stimulate catabolism of triglyceride-rich lipoprotine

Fexofenadine (Allergra)
Allergra D 12hr : 60mg + 120mg of pseudoephedrine ER
Allergra D 24hr : 180mg + 240mg of pseudoephedrine ER

Fluvastatin (Lescol XL)
HMGCoA reductase inhibitor 20mg qPM max 80mg
Tx: hypercholesterolemia

Fosinopril (Monopril)
ACEI 10, 20, 40 mg
Tx: hypertension and heart failure

Part 6

Truvada (emtricitabine + tenofovir)
emtricitabine (Emtriva) nucleoside reverse transcriptase inhibitor
tenofovir (Viread) nucleotide reversetranscriptase inhibitor

Erlotinib (Tarceva)
antineoplastic (tyrosine kinase inhibitor: EGFR inhibitor)
Tx: advanced/ metastatic nonsmall-cell lung cancer
25,100,200 mg tablet

Eszopicione (Lunesta)
nonbarbiturate sedative/ hypnotic

Estradiol Transdermal (Climara, Vivelle, Estraderm) 4, 8mg
Tx: moderate symptoms of menopause
hypogonadism

Part 5

Clindamycin (Cleocin)
inhibits bacterial protein synthesis by binding to 50s ribosomal subunits
static or cidal depends on "drug conc, infection site, and organism"

Diltiazem (Cardizem, Catia XT, Dilacor XR, Tiazac, Taztia XT)
Calcium Ch Blocker
use in: hypertension, chronic stable angina
PSVT, AF (both fibrillation and flutter)
Diprivan (Propofol)
general anesthetic/ sedative
for outpatient surgery
inj 10mg/ml

SIN DRUG has first dose effect (BP drop, syncope, tachycardia)
Doxazosin (Cardura)
alpha1 blocker tx: hypertension, BPH, urinary outflow obstruction

Prazosin (Minipress)
alpha1 blocker tx: BPH, Raynaud's syndrome

Terazosin (Hytrin) 1-20mg at bedtime

Alfuzosin (Uroxatral)

Tamisulosin (Flomax)

Part 4

Cetuximab (Erbitux)
Tx colorectal cancer (inj 100mg/50ml)
mechanism of action: binds epidermal growth factor receptors then inhibits cell growth and survival

Clarithromycin (Biaxin)
MAC prophylaxis (in HIV patients) 500mg bid
H.Pylori 500mg bid for 10-14 days (with amoxycillin or metronidazole + PPI)
Biaxin XL: (500mg ER) acute maxilary sinusitis 1G qd for 14 days
chronic bronchitis 1G for 7days
CAP 1G 7days

Part 3

Carvedilol (Coreg)
anti hypertensive Beta blocker with alpha blocking activity
use in mild to severe HF of Ischemic or cardiomyopathic
Left ventricular dusunction following MI

3rd GEN cef
Cefdinir (Omicef)
sinusitis, pharyngitis, chronic bronchitis, pneumonia
bactericidal by inhibit cell wall mucopeptide synthesis
300mg cap BID or 600mg QD for 10days

2nd GEN cef
Cefprozil (Cefzil)
250,500mg tab

Cefuroxime (Ceftin, Zinacef)
250,500mg
1G once for gornorrhea (uncomplicated)

1st GEN cef
Cephalexin HCl (Keflex)
general bacterial infections
endocarditis prophylaxis 2G once give 1 hour before dental or other oral procedures

Part 2

Ziac (Bisoprolol 2.5/5/10mg + HCTZ 6.25mg)
Anti hypertension drug
Bisoprolol (Zebeta) 5/10 mg

Budesonide (Rhinocort Aqua, Pulmicort Respule, Entocort EC)
anti-inflammatory (steroid)
Entocort EC comes in tablet for tx of Crohn's disease: 9 mg qam max 8 weeks
Capecitabine (Xeloda)
antineoplastic for metastatic breast cancer/ colorectal cancer
is a prodrug of fluorouracil (Fluroplex, Adrucil, Efudex, Carac) (inhibits thymidylate synthetase)

Carisoprodol (Soma)
skeleton muscle relaxant 350mg (centrally muscle relaxant)

Casprofungin acetate (Cancidas) IV
antifungal for tx of aspergillosis, febrile neutropenia
refractory, canicemia, candidiasis
Mechanism of Acion : inhibits fungal cell wall synthesis

Top 200 drugs in ths U.S.

Adalimumab (Humira)
antibody for human TNF used in Rheumatoid Arthritis (inj prefilled syringe 40mg/ml)

Alendronate sodium (Fosamax) 5,10,40 mg
Tx: Osteoporosis and Paget's disease
dose: 70mg/wk or 10mg/day
prevention 35mg/wk or 5mg per day
Paget's 40mg/day for 6months

Lotrel (Amlodipine 2.5mg + Benazapril 10mg)
Anti hypertensive drug
Amlodipine (Norvasc) Calcium Ch Blocker 2.5, 5, 10mg
Benazapril (Lotensin) ACEI 5,10,20,40 mg
Anastrozole (Arimidex)
antiestrogen for breast cancer: 1 mg qday

Atazanavir (Reyataz)
Protease Inhibitor for HIV infection: 400mg qday

Antiparkinsonian Drugs

Parkinson’s disease is a degenerative disease of the nervous system.

Sign & symptom:
Involuntary tremulous movement (rigidity)
Pill-rolling motion of hands

Dopamine does not cross Blood Brain Barrier. Therefore, we use levodopa which is a dopamine precursor and levodopa can pass BBB. Levodopa is metabolized to dopamine by dopa-decarboxylase enzyme. In order to prevent peripheral side effect from increasing level of dopamine, we use carbidopa. Carbidopa inhibits peripheral decarboxylation of levodopa and carbidopa cannot pass BBB. Hence, level of levodopa in blood stream will increase and absorb through BBB. The combination of levodopa and carbidopa is available in tablet known as Sinemet.

Pramipexole or Mirapex is a selective dopamine receptor agonist (D2).

Ropinirole or Requip is also selective dopamine agonist (D2).

Drugs & Their Antidotes

§ Acetaminophen Acetylcysteine
§ Benzodiazerpine Flumazenil
§ Digoxin Digoxin immune fab (Digibind)
§ Dopamine Phentolamine
§ Heparin Protamine Sulfate
§ Iron Deferoxamine
§ Methotrexate Leucovorin
§ Morphine and opiates Naloxone, Naltrexone
§ Nitrogen mustard Sodium Thiosulfate
§ Organophosphates 2-PAM (Pralidoxime)
§ Warfarin Phytonadione (Vit K)

Welcome to MYNAPLEX

I am going to take this test soon. Then I think why don't I just create a blog so that everyone can share the info. I am a Thai pharmacist who currently lives in Chicago. My goal of building this blog is to share my knowledge about all pharmacy stuffs.

This would benefit to not only blog readers but also myself as I can review each part of pharmacy knowledges. Please feel free to add yours or even correct me if I have some incorrect or not up-to-date information.

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